The Ohio River offers anglers some good fishing opportunities in Southern Indiana. On the river, anglers target largemouth bass, smallmouth bass, catfish, bluegill, crappie, walleye, sauger, white bass, yellow bass and more. If you fish with live bait, you may end up catching so many different species while fishing the river. If you use lures that replicate smaller minnows, you will also have a good chance to catch a variety of different fish. The river provides anglers with good action when the bite is on and there are some quality fish in the river as well. This part of the river is known for producing some very large catfish and there are guides that do target them here.