The Apalachicola River runs from Lake Seminole, on the Florida-Georgia border at Chattahoochee, 106 miles south through the Panhandle to the Gulf of Mexico, at the town of Apalachicola. The best fishing in this river is in the upper river and the lower river.
Upper River
The upper river is quite the drive, so most anglers do not consider fishing this part of the river while here on a vacation. It does offer good fishing for largemouth bass even though few anglers take advantage of it.
Lower River
The lower river consists of the main river channel and the tributaries which form the delta: the St. Marks River, Little St. Marks River, and East River. Striped bass and sunshine bass are stocked in the lower river. Largemouth bass and catfish are here as well. As you get closer to Apalachicola Bay, you will find brackish water, which will hold some freshwater and saltwater species.